pSTR Finder: a rapid method to discover polymorphic short tandem repeat markers from whole-genome sequences
نویسندگان
چکیده
منابع مشابه
General approach to analysis of polymorphic short tandem repeat loci.
Polymerase chain reaction amplification products of 22 known polymorphic short tandem repeat (STR) loci were subjected to denaturing polyacrylamide gel electrophoresis and detected using a silver staining method. Loci that amplified efficiently and revealed the fewest amplification-related artifacts with this detection method were selected for development of allelic ladders. The combination of ...
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A tandem repeat in DNA is two or more contiguous, approximate copies of a pattern of nucleotides. Tandem repeats have been shown to cause human disease, may play a variety of regulatory and evolutionary roles and are important laboratory and analytic tools. Extensive knowledge about pattern size, copy number, mutational history, etc. for tandem repeats has been limited by the inability to easil...
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ژورنال
عنوان ژورنال: Investigative Genetics
سال: 2015
ISSN: 2041-2223
DOI: 10.1186/s13323-015-0027-x